The disease is manifested only in males who have inherited the trait from their mother and occurs in about one of every 10,000 male births.
Interestingly, I've never heard a straight man relate that he knew he was heterosexual before his first crush on a girl, which probably adds to the inability to recognize that our sexuality is more than what is manifested only in relationships.
If this were the sole defect, then susceptibility should be manifested only in the context of an adaptive immune response.
It is also possible that differentiation in I. parviflora is manifested only in early developmental stages; considerable differentiation was recorded for time of germination and frost resistance of its seedlings (Skálová et al., 2011).
Exposure to pharmacological doses during development (in utero and early post natal period), the period during which HP axis differentiation and sexual dimorphism occurs (Rhind et al., 2001; Robinson, 2006), was found to be potentially more detrimental than later exposure and was seen to induce effects on reproductive function/physiology which were manifested only in later life.
QTL × environment effects were also significant for one QTL affecting each of days to bolting, fruit length, seeds-per-fruit, and seed mass, indicating that at least some of the genetic loci affecting each reproductive character, except seed color, were environment-specific or that functional differences between alleles at these QTL were manifested only in one environment.
A comprehensive lipidomics analysis of subcellular organelles isolated from resting and activated macrophages found that during macrophage activation some changes in lipid composition occur in all organelles, whereas other changes are manifest only in specific organelles [59].
These data not only show that RecANg is faster at nucleating onto SSB-coated DNA than RecAEc, but also that SSBNg is a greater barrier to RecA nucleation than is SSBEc, perhaps due to unique features of the SSBNg protein that are manifest only in the ATPase assay, since the efficiency of strand exchange was not affected by replacing SSB (data not shown).
Of course, this does not mean that the gene is useless, only that its effects are covered by redundant systems, that its benefits are manifest only in special situations, or that the benefit is just too small to be observed in a laboratory setting.
