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The phrase "are major obstacles" is correct and usable in written English.
It can be used to describe significant challenges or barriers in various contexts, such as projects, processes, or personal situations.
Example: "The lack of funding and resources are major obstacles to the success of the initiative."
Alternatives: "are significant challenges" or "are substantial barriers."
Dictionary
are major obstacles
noun
A military rank between captain and lieutenant colonel
Exact(60)
Still, there are major obstacles.
"These are major obstacles," said David J. Herman, head of General Motors in Russia and the former Soviet Union.
She said the costs of land and health care are major obstacles for most would-be farmers.
Ignorance and superstition are major obstacles to overcome in rural villages, where dangerous home deliveries are commonplace.
While the technology may be there, the fear of sharing data with competitors and the lack of consumer demand are major obstacles.
Vaccine delivery and health worker shortages are major obstacles for some developing countries, although Gates said he didn't believe more money should be diverted from the cost of vaccines to meet costs for infrastructure.
Maybe Boisselier was thinking of her passionate volunteers when she said that she "didn't think there are major obstacles, actually, since cloning has been demonstrated in other mammals, and the technique has been refined.
And the very sources of Australia's clean energy — its vast outback and nearly 60,000 kilometers, or 37,000 miles, of coast — are major obstacles to linking new, remote power sources into the grid.
– Illegal settlements in East Jerusalem and the West Bank and the blockade of Gaza are major obstacles to a durable agreement, supported by the UK, based upon the co-existence of two states, Israel and Palestine.
Veteran teachers can also be at risk of dismissal because they are not cronies of their principal, are "union people" or work in schools where student attendance and lack of parental involvement are major obstacles to student success.
But there are major obstacles.
More suggestions(15)
are substantial obstacles
are serious obstacles
are considerable obstacles
are fundamental obstacles
are enormous obstacles
are main obstacles
address major obstacles
present major obstacles
are major props
are major catches
are major results
are major players
are major industries
are major differences
are political obstacles
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com