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The phrase "are major issues for" is correct and usable in written English.
It can be used to indicate that certain problems or challenges significantly affect a particular group, situation, or context.
Example: "Climate change and pollution are major issues for urban communities striving for sustainability."
Alternatives: "are significant concerns for" or "pose serious challenges for".
Exact(8)
These are major issues for people who manage enterprise networks.
As Kardashian says, loneliness and isolation are major issues for people with mental health problems.
Safety and reliability are major issues for the ASDEX Upgrade (AUG) pulsed power supply systems.
Inevitable noises and limited computational time are major issues for time-variant matrix inversion in practice.
Nevertheless, low resistance to oxidative degradation and poor low temperature properties are major issues for palm oils to be used as lubricant [3].
Access to both the health care system and the disability system are major issues for our veterans, which makes the reports of "secret lists" all the more alarming.
Similar(52)
Certainly there are major issues ahead for the idea.
Major issues But despite this there are still major issues for further education.
Social reform and the security of the Taiwanese are two major issues for the new government.
Unfortunately, there are several major issues for this scheme.
I don't think it's been a major issue for science today but the danger is it will be a major issue for science in the future.
More suggestions(2)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com