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The phrase "are major impediments" is correct and usable in written English.
It can be used when discussing significant obstacles or challenges that hinder progress or success in a particular context.
Example: "The lack of funding and resources are major impediments to the project's completion."
Alternatives: "are significant barriers" or "are substantial obstacles."
Exact(15)
Structural problems, however, are major impediments to economic growth.
A large trade deficit and a high rate of unemployment are major impediments to economic progress.
But access and cost are major impediments to a strict GF diet, especially for those on low incomes.
For difficult-to-machine materials such as mold and die steels or ceramics, limited cutting tool/machine stiffness and strength are major impediments to the efficient use of mechanical micromachining methods.
The issues that confront today's Western leaders are major impediments to a safe and prosperous Western world.
Involving parents effectively looks different in different places, and there are schools in which eyeglasses and other health concerns can be assumed to be taken care of and others where they are major impediments to success.
Similar(45)
In fact, non-white skin or a foreign surname continue to be major impediments to progress within France.
"And conditions remain brutal in the middle and upper ranges of the spectrum, with rising unemployment and prices that are still considerably too high in many markets being major impediments to gains in activity".
However, the high density of microtubules in the central spindle and the presence of mitochondria were major impediments.
Lack of information and/or concerns about side effects were major impediments to DMARD use.
In short, interoperability and integration complexity were major impediments to the direct application of the NER-related aspects of the collaboration to the CTD pipeline.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com