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The phrase "are major changes in" is correct and usable in written English.
It can be used when discussing significant alterations or modifications in a particular context, such as policies, systems, or conditions.
Example: "There are major changes in the company's management structure that will affect all employees."
Alternatives: "significant alterations in" or "substantial modifications in".
Exact(13)
Former Liberal leader Mr Jo Grimond (L. Orkney and Shetland) repeated his preference for a federal system saying: "unless there are major changes in the Bill I shall vote against the third reading.
While more American troops can help to stabilize southern Afghanistan, that argument goes, they cannot turn the situation around in the country unless there are major changes in overall policy.
Unless there are major changes in the rules for going public, this trend seems here to stay.
While the geomagnetic latitude differences are relatively small, there are major changes in the vertical cutoff rigidity values for these same locations over this 150-year period.
"The likelihood of this lawsuit succeeding is slim, unless there are major changes in Supreme Court precedent," Skagg explained.
As are major changes in opinion on major social issues, with immigration following along the path of growing support for same-sex marriage.
Similar(47)
Whatever the final outcome, there will be major changes in the live comedy landscape.
"There have been major changes in the farm industry," Mr. Lee said.
After the game, a furious Edwards said there could be major changes in the lineup.
Not surprisingly, however, there were major changes in the plays during and after Reconstruction.
There are going to be major changes in the Nocsae standard".
More suggestions(19)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com