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The phrase "are major challenges" is correct and usable in written English.
It can be used when discussing significant difficulties or obstacles in a particular context or situation.
Example: "The current economic conditions are major challenges for small businesses trying to survive."
Alternatives: "represent significant obstacles" or "pose substantial difficulties."
Exact(60)
Of course, there are major challenges.
But there are major challenges to collecting data on VOCs.
Increasing cell survival and promoting implant vascularisation are major challenges.
I'm hopeful that it is possible to reduce homicide, but there are major challenges.
There are major challenges facing the war effort, he said, "But we will win".
"It's not going to be easy...there are major challenges," he said.
What are major challenges in developing countermeasures (e.g., content moderation and freedom of speech)?
What are major challenges facing foreign-born entrepreneurs under current U.S. immigration policy?
The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology.
There are major challenges in establishing effective communications between nodes in Vehicular Ad Hoc Networks (VANETs).
Energy consumption and control performance are major challenges in event-based control.
More suggestions(15)
are primary challenges
are broad challenges
are large challenges
are substantial challenges
are important challenges
are severe challenges
are major threats
are great challenges
are major constraints
are major disadvantages
are considerable challenges
are major difficulties
are tremendous challenges
are major tasks
are serious challenges
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com