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"are mainly unknown" is grammatically correct and can be used in written English.
Example: The long-term effects of this medication on children are mainly unknown, as it is a relatively new drug.
Exact(16)
One candidate represents the status quo, another is plugging reforms that would support a core of basic researchers and grant more independence to the 300-odd Academy institutes, and a third's views are mainly unknown.
However, the genetic and epigenetic mechanisms that lead to their up-regulation are mainly unknown.
Moreover, the influence of familial factors (genetics and family background) on the associations are mainly unknown.
The problem is that these intricate biological networks are mainly unknown.
Vaccine costs are mainly unknown and were based on unofficial sources.
The cell-signaling pathways that characterize alternative regeneration pathways are mainly unknown (Batusic et al. 2005).
Similar(44)
Their etiology is mainly unknown.
There are multiple sources and routes of transmission of Cryptosporidium, and the load of disease attributable to each is mainly unknown.
He's mainly unknown because he refuses to promote his music in any way, and he's too shy to perform live.
Despite a widespread distribution in the central nervous system (CNS) [14] [17], 5-HT2B receptor function in the brain is mainly unknown.
Its function is mainly unknown, but it was highest expressed in the subcutaneous fat alone, which indicates a possible role in the peripheral regulation of obesity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com