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Other authors have previously indicated that cell senescence-related genes are localized on human chromosome 4 as introduction of normal human chromosome 4 into three immortal cell lines resulted in loss of proliferation and reversal of the immortal phenotype [41].
17 PAR-2 are localized on human skin mast cells.
Carbohydrate ligands that bind L-selectin are localized on human endometrial luminal epithelium at the time of implantation, whereas the trophoectoderm expresses L-selectin strongly after hatching (Genbacev et al., 2003).
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DYRK1A, which gene is localized on human chromosome 21, is a protein kinase that belongs to an evolutionarily conserved family of proteins known as DYRKs (dual-specificity tyrosine- Y -phosphorylation regulatyrosine- Y -phosphorylationrse functyrosine- Y -phosphorylationnt, gregulatedapoptosis [7]–[9].
However, UBE3A is localized on human 15q.
TOP1MT is localized on human chromosome 8q24.3.
The TRPS1 gene is localized on human chromosome 8q23-24.1, a region highly amplified in several cancers, especially prostate cancer and breast cancer, indicating that TRPS1 may be overexpressed during development or progression of these endocrine-related cancers [ 10].
Interestingly, it has been demonstrated that Toll-like receptors 1, 2, 4 and 9 are localized on the surface of human platelets, and thus an effect of endotoxins on platelets in sepsis has been hypothesized [ 6].
Mammaglobin A, lipophilin B, and most of the human secretoglobins are localized on chromosome 11q13, where they form a dense cluster [ 1].
In mitotic human cells, rDNA clusters are localized on the short arm of the five pairs of chromosomes 13, 14, 15, 21 and 22 and are termed NORs.
In humans, Ku p70 and Ku p80 genes are localized on different chromosomes (22q13 and 2q33, respectively).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com