A proteomic analysis revealed that habituation to DCB is linked to modifications in several metabolic pathways.
However, mechanisms inducing such changes are underinvestigated and, probably, may be linked to modifications of the cell surface and/or interactions with the membrane.
However, CgA also shows ultradian variation, which does not appear to be linked to modifications of catecholamine release [ 36, 37].
Thus, the improvements in cardiovascular function that these investigators found may be linked to modifications of vascular or inflammatory biomarkers.
In summary, the kinetics of placental and foetal growth altered by ART may be linked to modifications in various biological pathways, probably triggering the placental compensation phenomenon.
We then analyzed whether the observed changes in IGFBP-3 expression and promoter methylation were linked to modifications affecting the activation of the IGFIR/AKT cellular pathway, which could explain the observed differential sensitivity to ionizing radiation.
Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Some roles of the Tβ4 and Tβ10 couple are linked to a subtle modification of their relative amounts [11].
Using an informatics approach, Dixon and colleagues [ 7] showed that the cyclodehydratases that modify microcin B17, patellamides and other classes of peptides are extremely abundant in bacteria and are linked to diverse other posttranslational modifications.
Identification of predictive factors that are linked to outcomes may allow modification of surveillance strategies for sub-groups of patients and the need for research in this area has been highlighted by an expert panel of ASCO[ 9 ].
