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Proteoglycan (PG) loss and surface roughening, early signs of osteoarthritis (OA), are likely preceded by softening of the ground substance and the collagen network.
Magmatic episodes are likely preceded by an increase in the number of phreatic events.
Protein misfolding and aggregation, processes involved in several neurodegenerative diseases, are likely preceded by conformational changes in the proteins involved [8].
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Especially, the reduced expression of PGC-1α, mitochondrial biogenesis, altered mitochondrial membrane potential, abnormal fragmentation and cristae disorganization are likely preceding C-II loss and reduction in Ip levels.
The great 1857 earthquake there was likely preceded by a Parkfield quake that, 9 hours later, triggered the much bigger quake to the south.
The intramolecular cyclization necessary to reach this final structure, which is the creation of a bond between N and N of hydroxyornithine, is likely preceded by some further activation of the hydroxylamine, but no candidate enzymes have yet been established.
The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS) lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC.
Since metabolic changes under treatment are likely to precede anatomic alterations [3 5], FDG-PET/CT is actively investigated as a way to assess tumour response to chemotherapy (CT) and radiotherapy (RT) in lymphomas [6, 7], non-small cell lung [8 10], head and neck [11], and colorectal and breast cancers [12].
As pregnancy involves complicated and dynamic interactions between the endocrine and immune systems, it is possible that it could have differential effects on the development of an autoimmune disease depending on its timing or even complexity relative to the events that are likely to precede obvious clinical disease [1].
Moreover, brain changes are likely to precede cognitive changes, which would further explain this dissociation.
MRI findings are likely to precede clinical symptoms and support repeat MRI in the follow-up of a MOM hip.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com