The phrase "are largely understood" is correct and usable in written English.
It can be used when discussing concepts, ideas, or phenomena that are generally comprehended by a significant number of people.
Example: "The principles of physics are largely understood by students who have completed their introductory courses."
Alternatives: "are mostly recognized" or "are generally comprehended."
The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease.
The genetics of early-onset AD are largely understood with mutations in three different genes leading to the disease.
The importance of LA in plants is widely recognized (Linhart and Grant 1996; Johnson et al. 2010), and the mechanisms by which it operates are largely understood (Kawecki and Ebert 2004).
Although a large proportion of imported animals are destined for biomedical research (in which potential occupational risks are largely understood and quarantine procedures likely mitigate risk), a greater proportion (even among the high-risk genera) are destined for commercial use and therefore could expose a wider group of persons to zoonotic diseases.
It is largely understood that the new government is probably less powerful than the shadow one that rules from the royal palace.
But he added: "It is largely understood that 'governing body with full executive powers' clearly meant that the president would have no role in the transition".
For the most part, environmental security is largely understood to be about threats to the nation-state rather than to the environment per se, to other states, or to individuals.
This investigation was chiefly conducted as a proof-of-principle study, and therefore we made use of 18F-FDG since the effect of isoflurane on this tracer is largely understood [2, 4].
Lastly, case studies will be described that illustrate how recent successes in the development of microvascular networks for various biomedical applications can be largely understood in the context of the mechanical and biochemical factors reviewed in this chapter.
The crux of the present study is that we conjecture that changes in age-related offending patterns in the context of overall widespread drops in many crimes can be largely understood using the theoretical framework of crime opportunity theory and the security hypothesis that was described earlier.
