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The phrase "are largely restricted" is correct and usable in written English.
It can be used to describe limitations or constraints that apply to a particular subject or situation.
Example: "The resources available for the project are largely restricted due to budget constraints."
Alternatives: "are mainly limited" or "are primarily confined".
Exact(60)
For the GOT1Sd/ GOT1Sr pair the inter-paralog gene conversion events are largely restricted to the exonic sequences with a large intron becoming largely un-alignable between paralogs.
In mainland China, investors are largely restricted from investing overseas.
Grapes are largely restricted to marginal farmland and are of declining importance.
Three-year-olds are largely restricted to inferring number after separating out conceptually paired items.
Meantime, detecting them in living tissues are largely restricted by biocompatibility of probes.
And in mainland China, investors are largely restricted from investing overseas.
Now, Mexican birds are largely restricted to private ranches, hunting preserves, and a handful of wildlife preserves.
In mammals, except for a few cases, epidermal scales are largely restricted to the tails and paws.
Previous numerical and experimental studies on rolling shear are largely restricted to Norway spruce (Picea abies (L).
Follicular dendritic cells (FDCs) are a specialized type of antigen-presenting dendritic cells that are largely restricted to lymphoid follicles.
Despite robust lorazepam effects on multiple measures of neurocognitive function, differential age effects are largely restricted to dual‐task performance.
More suggestions(16)
are primarily restricted
are essentially restricted
are largely confined
are largely constrained
are predominantly restricted
are virtually restricted
are greatly restricted
are basically restricted
are considerably restricted
are largely regulated
are largely hampered
are mainly restricted
are generally restricted
are principally restricted
are largely finite
are largely small
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com