The phrase "are largely implicated in" is correct and usable in written English.
It can be used when discussing the involvement or responsibility of certain factors or entities in a particular situation or issue.
Example: "The researchers found that several environmental factors are largely implicated in the decline of bee populations."
Alternatives: "are significantly involved in" or "play a major role in".
Histidine kinases (HK) are largely implicated in environment sensing and stress responses in fungi [ 41].
MMPs are largely implicated in promoting angiogenesis and tumor metastasis [ 16, 17].
Local factors are largely implicated in inducing mammary involution [ 8– 10].
In pathogenic and parasitic fungi, ATP-binding cassette (ABC) transporters are largely implicated in defense mechanism and protect the fungus from secondary metabolites or toxins produced by the host [ 42].
A potential candidate for a transmembrane protein partner of the 500-kDa complex is the low-density lipoprotein (LDL) receptor related protein (LRP1), which is a large scavenger receptor mediating endocytosis of various biological components and is largely implicated in cytoskeleton organization [ 7, 62, 63].
Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders.
The plasminogen activation system is largely implicated in pathological angiogenic processes.
Gap junctions have also been shown to be largely implicated in the mediators- and endothelium-related relaxation [5], [30].
MMP-2 is largely implicated in promoting angiogenesis and tumor metastasis.
These twelve genes were largely implicated in colonization (e.g. binding fibronectin, bone sialoproteins) and immuno-modulation (e.g. IgG binding, clumping factor A) [ 30, 32, 40, 46].
For instance, RANTES and IL-8 are elevated in plasma of obese individuals [ 31– 33] and have been largely implicated in obesity-related health complications [ 34– 36] as well as in the mechanisms of cancer progression [ 37– 37].
