The phrase "are largely established" is correct and usable in written English.
It can be used to indicate that something has been mostly or predominantly set up or recognized in a particular context.
Example: "The guidelines for the project are largely established, allowing the team to proceed with confidence."
Alternatives: "are mostly set" or "are primarily recognized".
Synaptic contacts are largely established during embryogenesis and are then maintained during growth.
The inter-canine and inter-molar widths are largely established during the deciduous dentition and do not increase drastically during growth and development.
The U.S. company raised strategic funding from Baidu — which included an integration with Baidu Maps and other services — but Kuaidi Dache and Didi Dache are largely established among drivers and consumers already.
This indicates that the basic cell architectures of early embryos are largely established by the autonomous activities of the mitotic apparatus, without much dependence on the cell cleavage machinery.
In the hemimetabolous mode of development, the key features of the adult body plan are largely established during embryogenesis.
DNA methylation patterns which are largely established in-utero, induce stable changes in gene expression that may be sustained throughout the life span of an individual [33].
The understanding of hematopoietic cell functions has been largely established by the identification of a large number of effector genes expressed in hematopoietic cells, but has not been extensively substantiated at the AS level.
The Financial Times says today is "Decision Day" for the bailout fund, and suggests several conditions that could be added: Previous judgments have insisted on closer Bundestag control over EU legislation, but that has now been largely established.
As the climatic setting of such mountains is largely established tectonically, it may endure in the same climate for scores of millions of years and, as noted in 1901 by the American geomorphologist Douglas W. Johnson, a desert mountain range tends to bury itself in its own waste.
While forensic psychiatric aftercare with a focus on risk assessment and assertive treatment has been largely established, preventive care of high-risk psychiatric patients to avert delinquency, compulsory hospitalization, or forensic courses has not yet been developed.
