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The phrase "are largely different" is correct and usable in written English.
It can be used to describe two or more subjects that have significant differences between them.
Example: "The two proposals are largely different in their approach to solving the issue at hand."
Alternatives: "are significantly different" or "differ greatly".
Dictionary
are largely different
adverb
In a widespread or large manner.
synonyms
Exact(52)
A closer observation (Fig. 10) identifies that the activation values of those pixels are largely different.
First of all, the data sizes between waves and particles are largely different.
Otherwise, if the calculated and actual resources load are largely different, the hypervisor revokes some resources from the VM.
These spectra have similar line shapes; however, the positions of their emission peak and intensities are largely different.
Finally, the predicted assimilation outcomes differ remarkably between the static and the dynamic model, especially when the magnitude of state dependence of natives and immigrants are largely different.
In a ternary differentiated authority, the authority statuses of principals are largely different, and principals are more likely to compare with principals who have similar functions and status.
Similar(8)
The chromosome number is largely different from the chicken karyotype (2 n=78) because of the remarkable difference in the number of microchromosomes.
It's not long since I was last there, but this is early autumn, so the audience will be largely different from last time.
But this kind of empathy is largely different from the emotive response — the life-changing event — that reading a great novel can bring about.
PBDE congener profile in reindeer was largely different than in Baltic herring and grey seal.
This indicated that the composition of field water and that of model solution were largely different.
More suggestions(19)
are basically different
are broadly different
are largely divergent
are significantly different
are widely different
are virtually different
are generally different
are overwhelmingly different
are largely dissimilar
are considerably different
are greatly different
are fundamentally different
are substantially different
are largely diverse
are largely other
are mainly different
are largely distinct
are principally different
are largely disparate
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com