The phrase "are largely constrained" is correct and usable in written English.
It can be used to describe limitations or restrictions that significantly affect a subject or situation.
Example: "The options available to the committee are largely constrained by budgetary limitations."
Alternatives: "are mostly limited" or "are significantly restricted".
Broader applications of polymer hydrogels are largely constrained by their poor mechanical performance.
Common design approaches such as parametric study or optimization are largely constrained by the assumptions and do not promote flexibility in the decision making process.
It is important to differentiate between fully data-driven models and models that are largely constrained using prior knowledge.
The Borana pastoralists depend mostly on livestock production where livestock feed resources are largely constrained by frequent drought and changes in LULC patterns (Desta and Coppock 2002; Angassa and Oba 2007).
'Registration 1' is a rough and fast estimation of non-rigid deformations performed on smaller size images, where the B-spline functions are largely constrained (increasing the weight γ of the penalty term in Eq. 3) to describe the more global deformations in the material.
In the absence of monetizing the provision of beneficial services such as clean water, infrastructure protection or the maintenance of biodiversity, economic opportunities in managed forest are largely constrained by the ability to produce high quality timber such as sawlogs or veneer (at least in Central Europe).
Buyout firms have been largely constrained by more stringent lending by banks.
In the feudal societies of the Middle Ages for example, the ability of any individual to accumulate material wealth was largely constrained by the amount of "things" they could reasonably possess.
A limitation of the latter approach is that expression of affinity tagged baits is largely constrained to engineered or unnatural cell lines, which results in the AP MS identification of PPIs that may not accurately reflect those seen in nature.
Foliar δ(13)C had a significant positive relationship with species successional status, indicating changes in foliar physiology related to growth and competitive strategy, but was not correlated with stand age, whereas soil δ(13)C dynamics were largely constrained by plant species composition.
