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The phrase "are large differences between" is correct and usable in written English.
It can be used when discussing variations or disparities between two or more subjects or items.
Example: "In the study, it was found that there are large differences between the two groups in terms of their performance."
Alternatives: "there are significant differences between" or "there are considerable differences between".
Exact(56)
Although few report that they refrain from seeking health care for economic reasons there are large differences between different groups in the population.
Overall, there are large differences between different interacting protein pairs with respect to the number of correlated mutation positions and motifs that coincide.
In addition, annotation using Pfam databases indicated that the domain structure of NRPS is also different for different species, suggesting that there are large differences between the secondary metabolites of different Trichoderma (see supplementary table S3, Supplementary Material online, for details of Pfam annotation).
For NSAIDs there are large differences between drugs and between different doses of the same drug in terms of upper gastrointestinal bleeding.
Generally, there are large differences between studies: e. g., different physiological status of the experimental units, different experimental design, different measurement methods, and laboratory technicians.
"Uefa is aware, that there are large differences between the comparative wealth of different clubs and countries, but Financial Fair Play does not have financial equality as its objective," a spokesman for European football's governing body said.
For example, among the 'Bricklayers' group there are large differences between Cara, Jessica and Luc in the different contexts.
Similar(4)
There are larger differences between certain pairs of C. botulinum group III strains than between some group III strains and C. novyi.
Exercise interventions have demonstrated improvement in different outcome measurements in frail older adults, however, there were large differences between studies with regard to effect sizes.
If this happens as the tropical cyclone approaches a coastline, there may be large differences between the forecast landfall positions and actual landfall.
At all measurement stations, there were large differences between the partitioning patterns of the single discharge events.
More suggestions(10)
are extensive differences between
are enormous differences between
are considerable differences between
are wide differences between
are broad differences between
are major differences between
are significant differences between
are vast differences between
arise large differences between
suggest large differences between
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com