Syt VII is involved in docking and fusion of vesicles with the plasma membrane where it participates in formation of the SNARE complex [75].
This lack of ubiquitous protein densities could be attributed to the low number of synaptic proteins that are expected to be involved in docking and exocytosis (van den Bogaart and Jahn, 2011); proteins could also be overlapping with the interface in projection and be masked by the high-contrast lipids.
SNARE proteins are involved in vesicle docking and fusion at nerve terminals, and undergo conformational changes, as well as cycles of assembly and disassembly, during exocytosis and endocytosis.
The upregulated genes are involved in leukocyte rolling and docking on endothelial surfaces of capillaries and leukocyte transmigration through capillary endothelial layers (Fig. 3).
Proteins that are involved in vesicular trafficking including docking and fusion/budding of small vesicles are also expected to localize within the tight junction membrane domain.
Alternatively, the modified conformation of violaxanthin-binding LHCII might affect the conformational changes [ 40], which are involved in detachment from PSII and docking to PSI [ 41].
As many peroxins are involved in matrix protein import (targeting, docking, translocation and receptor recycling) (see Introduction and Fig. 3), a lack of matrix protein import is often observed, whereas the synthesis of peroxisomal membranes and import of PMPs is unaffected.
Future studies will evaluate previously characterized Dock7 mutants (Zhou et al., 2013) to determine if structural elements in addition to the nucleotide exchanging DHR-2 domain of Dock proteins are involved in regulating Ca2+ mobilization in mast cells.
These phosphorylated residues serve as docking sites for proteins that are involved in regulation of intracellular signalling cascades.
This problem is avoided in the present case because the proteins we are docking co-exist in the same cellular compartment and are involved in the same pathway.
