No doubt there will be more cycles of hope and despair but these cycles have already been internalized through the startup journeys of the entrepreneurs we met.
Since the current implementation neglected heterodimerization of sVEGFR1 with surface VEGFRs, internalization of sVEGFR1 from the endothelial surface could only occur through binding to surface NRP1s; while VEGF could be internalized through the six signaling VEGFR complexes in addition to uncoupled NRP1s (Fig. 1B,C).
After attaching to the fibre receptor on the cell surface, Ad5 is internalized through the clathrin-coated-pit pathway [ 16].
After attaching to the fibre receptor on the cell surface, Ad5 is internalized through the clathrin-coated-pit pathway, and dynamin is required for the pathway [ 16].
In contrast with the depolarization caused by K+, which directly affects potassium channels, insulin is a cell-specific chemical stimulation that is internalized through the phosphorylation of receptor tyrosine kinases.
In the current study we confirm the concept of 'two endocytic routes-two outcomes' proposed for Wnt signalling (Yamamoto et al, 2008) and demonstrate that Dab2 expression levels regulate whether LRP6 is internalized through the caveolin or clathrin endocytic pathways.
So the lost object is internalized through this process of identification by which the individual now psychically takes on the attributes of the lost object, thereby acquiring a heterosexual gender identity (1990, 78 81; 1991, 26 7).
The receptors and activated ligand-receptor complex are internalized through two distinct endocytic routes, the clathrin-dependent endocytosis and the caveolar lipid-raft mediated endocytosis [9], [10].
In cultured neuronal cells, both oligomeric and fibrillar forms of α-syn are internalized through endocytosis and targeted to the lysosome for degradation 24, 46, 54, 61, 75, 77.
