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Demonstration that the developmental gene programs known to be targeted directly by nFGFR119,29 are indeed regulated by the nuclear receptor, and further substantiates the panontogenic-INFS theory20.
Pre-U exams, run by Cambridge Assessment, are "indeed regulated by Ofqual", as stated by the awarding body's chief executive (Letters, 14 July), but – as a recent reply to a freedom of information (FoI) request revealed – are not subject to the "additional rules" that apply to A-levels.
Therefore it is highly likely that many genes that are not in the RegulonDB target set are indeed regulated by Lrp.
Preliminary analyses of partial knockout of this gene indicate that at least some of these co-transcribed genes are indeed regulated by NF-Y (Lifang Feng and WM, unpublished observations).
We further examined whether thiamine-metabolic genes are indeed regulated by Phx1.
Whether Tgl3 and Tgl5 activities are indeed regulated during the cell cycle is not known.
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Thus, it remains a major task to confirm that APC is indeed regulated by miR-142 in BCSCs and determine the level of regulation in this context.
Given this functional similarity as well as recent zebrafish transgenesis assays showing that the miR-9 family is indeed regulated by HCNEs with enhancer activity, we hypothesized that this type of miRNA regulation is prevalent.
MakA expression was dramatically reduced implying that makA was indeed regulated by HapR (Supplementary Fig. 1A lane 2).
However, a significant number of genes in the pathway were indeed regulated, suggesting that, although the gene identities of the targets may differ between species, the function of the miR-34 gene in Wnt signalling inhibition has been conserved.
Importantly, these studies on wild type embryos show that Mad phosphorylation by GSK3 is indeed regulated in vivo.
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