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Whether a crowdfunding project could benefit from a pure or hybrid crowd design depends on the transaction costs and degree of information asymmetry at the different stages of crowdfunding as well as on whether adequate remedies are in place to overcome such challenges.
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Overall, the PDZ domain class 1 cross-reactivity identified here implies that auxiliary mechanisms must be in place to overcome this inherent functional overlap and to minimize cross-selectivity within the living cell.
Moreover, the numerical perturbations of the initial conditions were put in place to overcome the singularities of the integrations.
However, the participants also suggested measures that can be put in place to overcome this barrier.
In real-life clinical practice, measures could be put in place to overcome the slight loss of sensitivity or any negative consequences.
Beyond individual provider actions of kindness, facility-level initiatives, driven or supported by managers, were also in place to overcome access barriers and threats to the health care contract.
Alternatively this may suggest that the current solutions put in place to overcome the second delay are not sufficient.
That means ensuring we have protections in place to overcome that problem".
To overcome transcriptional noise, several regulatory mechanisms are in place to control gene expression dynamics and maintain optimal protein levels.
Cumulatively, all experimental models described earlier clearly revealed that NMO-IgG is pathogenic when it can overcome the constraints placed by an impermeable BBB and when additional cellular/molecular effector mechanisms are in place to amplify immune cascade.
Endemic problems in EU 'lagging rural regions' (LRRs) are well documented and various support mechanisms have long been in place to help overcome structural difficulties.
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