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Identification of novel CM genes and domains in humans will aid our understanding of fundamental epigenetic processes that are important for stem cell differentiation and cancer biology.
These results also indicated that cell-to-cell relationships, probably including paracrine factors, and cellular milieu are important for stem cell differentiation and development.
These gene expressions were observed in some somatic stem cells, and it is thought these are important for stem cell characteristics mainly to maintain their stem-ness.
In an effort to identify genes that are important for stem cell development, we have previously carried out tissue-specific microarray analysis of intestinal gene expression during Xenopus laevis metamorphosis.
The PcG proteins are important for stem cell maintenance and for cell fate determination during embryonic development, and disruption of epigenetic control can result in carcinogenesis (Boyer et al., 2006; Sauvageau and Sauvageau, 2010; Schwartz and Pirrotta, 2013).
Among the genes without RUNX1/ETO binding (pattern 011111) that were downregulated after RUNX1/ETO knockdown, we found the transcription factor genes ERG and ETV6 (TEL1), both of which are important for stem cell function and maintenance (Taoudi et al., 2011; Wang et al., 1998) but also have been implicated in AML (Diffner et al., 2013).
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And the CD44-positive cells also expressed genes that are important for stem-cell self-renewal, particularly one called Notch that controls the flow of chemical signals within a cell.Researchers at OSI Pharmaceuticals, a firm that makes a drug called Tarceva, found a similar pattern in lung cancer.
Development of biomaterials to control the fate of stem cells is important for stem cell based regeneration of bone tissue.
We have recently found that the gastric pathogen Helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while Wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues.
Stem strength i.e., the bending or breaking strength of the culm, is important for stem lodging resistance, particularly for the basal internodes of crops (Zuber et al., 1999).
Among the hub transcription factors, HAND1, HMGA1, MYCN and OCT4 are known to be important for stem cell development [27], [52] [54].
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