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In biophysical and biochemical point of view, N-glycosylation sites and O-glycosylation sites are important for functionality of the protein.
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Most proteins undergo some form of post-translational modification (PTM), which is important for functionality [39].
Residues in the ligand-binding domain known to be important for functionality of nuclear hormone receptors [ 24] are also conserved.
Routing algorithms are important for the functionality of a network because they provide paths on which the packets are sent over the network [15].
For many therapeutic proteins post-translational modifications, proteolytic processing and oligomerization of multiple chains are important for protein functionality, stability and efficient secretion.
It has been reported that dipeptides containing two residues separated by a distance along the sequence are important for protein functionality annotation in the work [ 65].
TTS are not part of sequences which are directly targeted by transcription factors, but their (human-mouse) conservation profiles suggest that they are important for gene functionality.
In summary, the specific anti-16E7 scFvs described in this paper exhibit characteristics which are important for their functionality in eukaryotic systems.
These patterns appear at every time point during the signal transduction in the network and they reveal information about the topology of the network, therefore are important for biological functionality [ 163].
GC servers are important for the UPN functionality of Active Directory.
This result suggests that phospholipids with specific headgroups are important for structure, maintenance and/or functionality of the LP surface.
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