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Mutations in conserved small RNA pathways for instance are important for developmental phenotypes in different tissues (Willman and Poetig 2005; Sunkar and Zhu 2007; Wang et al. 2007).
Here we focus on two specific questions that are important for developmental biology and which cannot be addressed by Boolean models – as originally proposed.
The first H2A ubiquitin ligases to be identified belonged to the Polycomb group (PcG) of transcriptional repressors, which are important for developmental patterning and maintenance of pluripotency (Sparmann and van Lohuizen, 2006; Schwartz and Pirrotta, 2007).
We searched the Epulopiscium genome for homologs of the newly discovered C. acetobutylicum Spo0A kinases that are important for developmental and metabolic transitions [ 69], however none of these appear to be conserved in the Epulopiscium genome.
In the spirit of highlighting points of importance for studies of this type I would suggest the authors consider a few additional points (or modifications) that, in my opinion, are important for developmental studies of navigation in rats.
The AhR is a member of the family of basic helix loop helix transcription factors that are important for developmental processes and involved in regulation of biological responses to aromatic hydrocarbons by inducing the expression of target genes (Beischlag et al. 2008; Hao and Whitelaw 2013).
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Increased expression in arrested L3 stages suggests that Ac-daf-7 is important for developmental arrest.
Thus, our findings of alternative TPH2 splicing suggests that this intron might be important for developmental processes, as 5-HT is known to be involved even in pre-neuronal growth regulation [8], [37], [38].
Buffering at a specific time during development might be important for developmental stability, so we evaluated the effect of a short-term exposure to a heat stress on morphological traits at the five times: one, three, five, seven, or nine days after the egg introduction (DAEI).
This kind of cell death mechanism may be important for developmental tissue remodeling [ 18].
Understanding how consistent left-right (LR) asymmetry of the body-plan is established is important for developmental biology and medicine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com