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In addition, the PI3Ks are implicated in the suppression of autophagy by acting upstream of TOR [ 39].
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Recently, SIRT2 has been implicated in the suppression of glioma formation (Li et al., 2013).
The let-7 miRNA family has also been implicated in the suppression of non-small cell lung tumor development [13] and colon cancer [13], [39].
Unlike Th1-mediated cytokines such as interferon-gamma that promote the killing of infected cells, regulatory cytokines including interleukin-10 have been implicated in the suppression of in vitro antigen-specific cellular immune responses in tuberculosis.
Moreover, the interaction of MV nucleoprotein with Fcγ receptor on antigen-presenting cells is implicated in the suppression of cell-mediated responses, [17], [18], [19] and in the induction of the T regulatory immune response, following a chronic exposure [20].
In addition, it has been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis.
OX40 OX40L interactions have also been implicated in the suppression of regulatory T cell function [4].
One of these miRNAs, miR-27a, has been implicated in the suppression of certain types of cancers.
Prak is a protein kinase, which was previously shown to be implicated in the suppression of skin carcinogenesis [ 34].
Nanos and Pumillio have also been implicated in the suppression of cyclin B mRNA in early development.
CD4+CD25+ T cells have been implicated in the suppression of arthritis in the susceptible DBA/1 strain [ 1, 2] and in patients with rheumatoid arthritis [ 3].
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