Synthesis and accumulation of sorbitol in cells due to aldose reductase (AR) activity is implicated in secondary diabetic complications.
Transcripts of CesA10, CesA11 and CesA12 genes are abundant in vascular bundles and these have been implicated in secondary wall cellulose synthesis [ 4].
Down regulation of vitamin D receptor (VDR) and decreased calcium sensing receptor (CaSR) on parathyroid cells have also been implicated in secondary HPT pathogenesis [ 3, 4].
Recently, the global regulatory velvet gene, A. fumigatus veA, has been implicated in secondary metabolite biosynthesis regulation, particularly with respect to gliotoxin [ 20] and fumagillin [ 22].
Additionally, genes encoding enzymes in methionine metabolism (homocysteine S-methyltransferases and methionine adenosyltransferases), cytoskeleton components (TUB, TUA, ACT), sucrose synthase (PtrSuSY1, PtrSuSY4), and encoding several AG P/FLAarabinogalactan proteins that have been implicated in secondary wall biosynthesis are among the most highly expressed genes.
The above have previously been implicated in secondary siRNA generation in other contexts (Yigit et al., 2006; Pak and Fire, 2007; Sijen et al., 2007) and drh-3, rrf-1 and MAGO -12 mutant strains are also sensitive to viral infection similar to rde-1.
The YLS has lost many genes that are implicated in detoxification of secondary metabolites, including loss of several cytochrome p450 and glutathione- S transferase genes that are found in M. anisopliae and N. haematococca, though it still maintains a single member of each of these families (data not shown).
In agreement with the results of our study, several authors have suggested that hip pathologies are implicated in the onset of secondary pathologies in surrounding anatomical structures [21, 58, 63, 64].
The AGE products are implicated in the functional microangiopathy, secondary to the increased blood cell viscosity and the consecutive reduction in blood flow.
Pro-inflammatory immune responses are thought to be responsible for the tissue damage that occurs in severe sepsis, while anti-inflammatory responses are implicated in the enhanced susceptibility to secondary infections [7].
