The ATP-dependent remodelers are implicated in many DNA transactions.
ROS are implicated in many pathologies, particularly in tumor disease.
Amyloid protein aggregates are implicated in many neurodegenerative diseases, including Alzheimer's disease and the prion diseases.
Microtubules are implicated in many essential cellular processes such as architecture, cell division, and intracellular traffic, due to their dynamic instability.
Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many different cancers.
Epidermal growth factor (EGF) receptor is the prototype of the ErbB (HER) family receptor tyrosine kinases (RTKs), which regulate cell growth and differentiation and are implicated in many human cancers.
Endothelial abnormalities are implicated in many diseases, including common acute conditions with high morbidity and mortality lacking therapy, in part because drugs and drug carriers have no natural endothelial affinity.
It is well established that dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receplays plan an important role in neurotransmission and that alterations in their functioning are implicated in many psychiatric disorders, including schizophrenia.
Chronic delta sleep deficits in humans are implicated in many diseases, including depression, heart disease, hypertension, obesity, chronic pain, diabetes and cancer, not to mention thousands of fatigue-related car accidents each year.
They are implicated in many metabolic disorders and diseases and are therefore important drug targets.
The basal ganglia (BG) are implicated in many movement disorders, yet how they contribute to movement remains unclear.
