Moreover, increased UCP2 expression has been implicated in limiting stimulus-secretion coupling in β-cells in some animal models of diabetes but not in others [31], [37].
Several studies have previously shown that transferrin is induced upon challenge [ 25, 35]; this protein seems to be implicated in limiting bacterial growth by sequestering iron [ 35].
The mechanisms by which sirtuin action increases longevity appear to be species-specific; aberrant rDNA recombination has not thus far been implicated in limiting lifespan in any organism aside from budding yeast.
45 IDO activity has also been implicated in limiting the severity of inflammation in mouse models of inflammatory bowel disease (trinitrobenezene sulfonic acid (TNBS) colitis) 46 and multiple sclerosis (experimental autoimmune encephalitis (EAE)).
The phenotypic analysis of MtN5-silenced roots showed that MtN5 is implicated in limiting root hair curling and that this role is necessary for an efficient colonization of nodule primordia.
When such competition exists in a system there is the risk of exclusion, either partially or totally, of one species by another and such mating competition has been implicated in limiting the distribution of another less common schistosome species, S. intercalatum, due to competitive interactions with S. mansoni (Tchuem Tchuente et al. 1995).
A large variety of cellular features have been implicated in limiting the life span of yeast mother cells, including DNA-repair by-products called extra-chromosomal ribosomal DNA circles (ERCs), carbonylated proteins, oxidized lipids (Nyström, 2005; Steinkraus et al., 2008), multi drug transporters (Eldakak et al., 2010), vacuolar pH and mitochondrial integrity (Hughes and Gottschling, 2012).
In particular, it will be essential to establish whether or not the genes in question are implicated in a rate-limiting process and to analyse the dynamics of the corresponding protein products, including their turnover, post-translational modifications and cellular localization.
57 68 On the other hand, the specificity of inflammatory biomarkers for osteoarthritis may be limited since they are implicated in a range of inflammatory conditions and the utility and significance of hs-CRP are generally limited in osteoarthritis when body mass index is taken into account.
Although results have indicated that iron-requiring proteins are implicated in DNA replication, repair and cell cycle control, limited information is available regarding their functional mechanisms.
