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Ubiquitously expressed calpain-I (μ-calpain) and calpain-II (m-calpain) proteases are implicated in development of apoptosis.
Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer.
Thus, several agents are implicated in development of abnormal angiogenesis in diabetes mellitus, including dysregulation of VEGF local expression [ 45, 46] and other growth factors or cytokines imbalances [ 47, 48] in a general metabolic derangement [ 49].
To discover genes downstream of Jarid2, we examined publically available gene-expression microarray data for Jarid2−/− ESCs (Shen et al., 2009) and found that among the 413 genes misregulated relative to controls (fold change > 2, p value < 0.05) many have roles in cell adhesion, the cytoskeleton, and extracellular matrix or are implicated in development.
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Galvanotaxis, the migratory response of cells in response to electrical stimulation, has been implicated in development and wound healing.
The sirtuin (SIRT /nicotinamide adenine dinucleotide (NAD) system is implicated in development of type 2 diabetes (T2D) and diet-induced obesity, a major risk factor for T2D.
Autonomic dysfunction, in particular under-regulation of heart rate (HR) by the baroreflex, is implicated in development of insulin resistance (IR).
D6 proteins have been implicated in development and cellular differentiation.
CD36 facilitates oxidized low density lipoprotein uptake and is implicated in development of atherosclerotic lesions.
POU domain proteins have been implicated in development, replication, growth and cell cycle arrest, and differentiation [4] [6].
Increased expression of FAT/CD36, FATP1, UCP2 and UCP3 have all been implicated in development of lipotoxic heart disease [20], [52], [53].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com