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D1-class receptors are implicated in cognitive deficits observed in schizophrenic patients [16], and may be related to a distinct cluster of 'negative' symptoms including social withdrawal [17], [18].
63 Cholinergic neurons that are implicated in cognitive functions may be regulated by oestrogens.
As the corpus callosum allows for functional interactions both within each hemisphere and between the two hemispheres, regions within the frontal, parietal, and occipital cortices that are implicated in cognitive domains are affected (Hinkley et al., 2012).
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In senescence-accelerated mouse, mitofilin is implicated in cognitive disorder associated with mitochondrial dysfunction (Wang et al. 2008).
Oxidative stress has been implicated in cognitive decline as seen during normal aging and in sporadic Alzheimer's disease (AD).
Neuropathological alterations in these same regions have been implicated in cognitive impairments of AD patients at an early stage of the disease.
The hippocampus shows a high susceptibility to mTBI-induced damage due to its anatomical localization and has been implicated in cognitive and neurological impairments after mTBI.
Alterations in amyloid beta precursor protein (APP) have been implicated in cognitive decline in Alzheimer's disease (AD), which is accelerated in Down syndrome/Trisomy 21 (DS/TS21), likely due to the extra copy of the APP gene, located on chromosome 21.
Among different neurotransmitters, serotonergic alterations have been implicated in cognitive alterations, and low extracellular serotonin levels seem to be associated with impaired learning and memory consolidation (Ramos-Rodriguez et al., 2013).
On the other hands, BDNF has been implicated in cognitive function, because it regulates synaptic plasticity [43] and animals with deletions of BDNF gene in brain areas that include hippocampus show deficits in synaptic plasticity [44] and cognitive impairments [45], [46], whereas animals with increased expression of BDNF show better performance in cognitive tasks [47].
Fucα1−2Gal has long been implicated in cognitive processes.
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