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Using this approach, we identify 17 TFs with high relevance scores, which are hypothesized to be responsible for the transcriptional changes in a TORC1-dependent manner.
Vorinostat has been reported to inhibit primarily HDACs 1, 2, 3 and 6, which are the ubiquitously expressed HDAC family members that are hypothesized to be responsible for unwanted side effects.
Current cancer therapies that target proliferating tumour cells can dramatically reduce tumour bulk but durable cures may require elimination of TICs that are hypothesized to be responsible for tumour growth, metastases and relapse.
While many factors are hypothesized to be responsible for this trend, BMD is thought to be a primary determinant, because it is the most consistent and robust predictor of fracture risk [ 1, 11].
Within the kilovoltage energy range, the radiosensitization effect is generally attributable to the photoelectric effect, while auger electrons are hypothesized to be responsible for energy radiosensitization within the megavoltage range of radiation energies.
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Therefore, the difference in specific growth rate is hypothesized to be responsible for the lower PHB production in the bioreactor cultivation.
A novel FGF-1/fibroblast growth factor receptor-1c dimerization interaction combined with non-phosphorylatable intracrine signaling is hypothesized to be responsible for these observed functional effects.
The difference between the intrinsic properties, i.e. its electrochemical activity, ionic conductivity, and reactivity of LSC and LCN materials was hypothesized to be responsible for the observed difference in the degradation profile.
Sleep deprivation and the subsequent decreased mental alertness and manual dexterity have been hypothesized to be responsible for these worse surgical outcomes during out-of-hours operating [10, 11].
Because of a highly conserved motif resembling the zinc-binding active site of nucleotide deaminases and essential for editing, the DYW motif of PPR protein was hypothesized to be responsible for the catalytic reaction but is still debated (Boussardon et al. 2014; Takenaka et al. 2014; Yagi et al. 2013; Wagoner et al. 2015).
Based on stable isotope experiments by other researchers, nitric oxide dismutase (nod) functional gene was hypothesized to be responsible for splitting nitric oxide to nitrogen and oxygen and this internally generated oxygen is utilized by n-DAMO prokaryotes to oxidize methane gas.
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