Sentence examples for are highly refractory from inspiring English sources
Because they are highly refractory, these compounds have been much investigated for use as fuels for nuclear reactors.
Also, HT-29 colorectal tumor xenografts, which are highly refractory to paclitaxel, showed complete regression after AZ10992 administered at 30 mg/kg/day (seven injections for 4-days).
Both diabetes mellitus and BD are highly refractory: less than half of the participants in the National Health and Nutrition Examination Survey (NHANES) met glycemic control goals (Koro et al. 2004).
Malignant gliomas, particularly recurrent anaplastic gliomas and glioblastoma multiforme (GBM) are highly refractory to therapy.
Similarly, mice expressing mutations which prevent nuclear translocation, heterodimerization of AHR with ARNT, or AHRE binding are highly refractory to dioxin-induced toxicities [ 11, 19, 20].
Further support for this model was provided by mismatch repair-deficient cells and mice, which are highly refractory to the killing effect of SN1 methylating agents (25).
Dr. Robert J. Motzer of Memorial Sloan-Kettering Cancer Center in New York, who was not involved in the study, said: "This is a novel treatment strategy that has produced encouraging results, in a cancer that is highly refractory to conventional therapy.
Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer death and has proved to be highly refractory to treatment.
The decision to discontinue treatment has a heavy burden of consequences, given that CM can be highly refractory to treatment, disabling, and associated with comorbidities including depression, anxiety, and medication overuse [6, 7].
In contrast to the other homopolymers, the dG10 oligomer proved to be highly refractory to hydrolysis by BAL 31.
As illustrated in Fig 4B, Jurkats were highly refractory to the effects of purified IFNα when compared to primary CD4+ T cells, including significant differences at concentrations of IFNα reflecting that induced by N. gonorrhoeae infection (50 U/ml, denoted with a box in Fig 4B).
