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Wnts are a large family (19 members in humans) of secreted lipid-modified glycoproteins that are highly evolutionary conserved.
The high percentage of essential CS genes led us to explore the possibility that CS genes are highly evolutionary conserved as a whole.
A number of longevity-associated genes (LAGs) was revealed by genetic manipulation in yeast, worms, flies, and mice; they are highly evolutionary conserved across all these model organisms (Budovsky et al. 2007; de Magalhaes et al. 2009).
However, cells can communicate more locally within organs or even talk to individual cells from other tissues using a lexicon of different signaling pathways, the majority of which are highly evolutionary conserved.
MiRNAs are non-protein-coding, small RNAs of 20 23 nucleotides (nt) that exist in virtually all organisms and are highly evolutionary conserved (Ambros, 2001) suggesting a superior role in essential biological processes.
By sequence alignment analysis of TEX11 homologues from diverse species (human, mouse, rat, horse, cat, dog, marsupial, chicken, and fish), we found that three of these mutations affect residues that are highly evolutionary conserved and may therefore be important for functional and/or structural integrity (W117, Q172, and V748; Supplementary Fig S1).
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We found that TFEB contains a CRM1 consensus hydrophobic sequence located at the N-terminal portion of the protein that is highly evolutionary conserved (Fig. 3a) and that is also present in other MiT-TFE members, such as TFE3 and MITF (Fig. 3b).
The 'low-road' affective process is highly evolutionary and is designed to protect individuals from life-threatening danger, and to elicit defensive responses without conscious thought.
Wnt/Wg pathway is highly evolutionary conserved and is considered as one of the most important developmental pathways (Clevers and Nusse, 2012).
The POU4F2 gene is highly evolutionary conserved and show a high content of CpG sites indicating that the gene could be regulated by methylation.
Much to our surprise, the EEVD C-terminus sequence motif only existed for HSP90 α, HSP90 β, and HSP70) and was highly evolutionary conserved.
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