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The phrase "are highly different from" is correct and usable in written English.
It can be used to emphasize a significant difference between two or more subjects.
Example: "The results of the two experiments are highly different from each other, indicating that the variables had a substantial impact."
Alternatives: "are significantly different from" or "differ greatly from".
Exact(7)
In addition, the characteristics of the three proposed along-strike segments in Fig. 3(b) (Johnson et al., 1996; Freymueller et al., 2008) are highly different from each other, including their pre- and post-seismic activities (Doser et al., 2006), (2008).
The picture gets blurry in some cases when commodities themselves have evolved and are hard to compare over time (e.g., poultry or soybean production today are highly different from what they were decades ago).
VLBW infants experience conditions that are highly different from normal growth in utero and could therefore be at particularly increased risk.
Figure 4 shows that tree topologies inferred using FLU are highly different from those inferred using other models.
The morphology and disease symptoms are highly different from the other three species, which led to the description of the genus Melanopsichium for the smut pathogens of Polygonaceae.
The same trend holds for the average clustering coefficients, path lengths and eccentricities; observed networks have average values that are not significantly different from one another but are highly different from the random networks.
Similar(53)
This negative value is highly different from the Bragg peak sensitivity, which completely fulfill the condition of Eq. (4).
The packaging densities of PE matrices were highly different from each other.
Edges hosted relatively large numbers of edge-related species, and proved to be highly different from habitat interiors with regard to life-form and geoelement spectra.
However, there is industrial evidence that the variability of the production output may drastically impact on the capability of managing the system operations, causing the observed system performance to be highly different from what expected.
However, there is industrial evidence that the higher moments of the production output may drastically impact on the capability of managing the system operations, causing the observed system performance to be highly different from what expected.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com