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Only five conformational ensembles for each structure are generated to minimize computational time (30 40 min for one drug).
While clinical trials are the only way to evaluate the immunogenicity, in patients, of murine or genetically engineered humanized variants of a potentially therapeutic or diagnostic monoclonal antibody (MAb), ethical and logistical considerations of clinical trials do not permit the evaluation of variants of a given MAb that are generated to minimize its immunogenicity.
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For example, regions can be generated to minimize the loss function discussed in section 2.1.
An LKAS system is proposed in this study such that the desired path is generated to minimize the trajectory overshoot.
Systematically introduced alterations were generated to minimize background expression while maintaining high levels of induced expression.
The splines are generated through minimizing a cost function subject to constraints imposed by a linear control system and accuracy is improved iteratively using a recursive spline algorithm.
and filters are generated by simultaneously minimizing relative errors in both detection channels [Eq. (11)].
Filters are generated by simultaneously minimizing relative errors in both detection channels [Eq. (11)].
Finally, self-supported slanting and pillar support structures are generated that minimizes support material consumption and consequently saving build time.
Recent advances in seasonal forecasting are generating new opportunities to minimize the impact of CV on health [ World Health Organization (WHO) 2004].
In order to achieve low computing cost and high image coding performance, multiple reduced images are generated by colorization error minimizing method, and the RPs are extracted from these reduced images.
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