RPS12 and RPS4Y1 are components of the 40S subunit of the ribosome, while RPL36AL is a component of the 60S subunit, functioning together in the cytoplasm to catalyze protein synthesis.
To date, mutations in at least 15 different genes have been identified that cause FA; the products of all of these genes are thought to function together in the FA pathway, which is essential for ICL repair.
This indicated that JAM-A, Rap1, and β1-integrin are likely to function together in a linear signalling pathway in breast cancer cells.
The HumanNet v1 is a probabilistic functional gene network made of 18714 validated protein-coding genes of Homo sapiens, constructed by Bayesian integration of 21 types of 'omics' data from multiple organisms, with each data type weighted according to how well it links genes that are known to function together in Homo sapiens.
In this respect, four particular pairs (i.e., ArcB/ArcA, CheA/CheB/CheY, BarA/UvrY and YehU/YehT) are exceptional in the sense that each corresponding partner resides at a different location of the chromosome, although each pair is known to function together in a certain signaling pathway.
It has been shown, for example, that genes with correlated expression patterns are more likely to function together in common biological processes (e.g., [ 41, 42]), and at least in yeast, proteins encoded by co-expressed genes are more likely to participate in direct physical interactions than random pairs [ 48].
Genes that are frequently co-expressed often function together in common processes (e.g., [ 41, 42]).
By finding gene ontologies, pathways and TRE motifs that were significantly enriched within individual clusters, genes that potentially functioned together in pathways were identified.
The aim of isolation, in a simulated Mars base, is to see how teams function together in a sealed environment – much like they would have to on a real long-duration mission.
Anti-silencing function 1 (and1) and Chromatin Assembly Factor (CAF-1) are chaperones of histones H3/ H4 that function together in the replication dependent chromatin assembly pathway.
