Like other T-BOX proteins in zebrafish (Bra, Ntl, Spt and Tbx6) (Wardle and Papaioannou, 2008), in Xenopus (Xbra, Xbra3, VegT and Eomes) (Gentsch et al., 2013) or in the mouse (Bra and Eomes) (Costello et al., 2011, David et al., 2011), human EOMES and BRA might be functionally interconnected in distinct developmental contexts.
All these factors affect neurogenesis in brain regions involved in depression and are functionally interconnected so that initial alteration in one of them results in abnormalities in the others [ 2].
This observation strengthened the idea that epsin and Hip1R are functionally interconnected, as suggested by studies in yeast and Dictyostelium (Baggett et al., 2003; Brady et al., 2010; Skruzny et al., 2012), and prompted us to explore the interplay of epsin and Hip1R.
In fact, such pathways are functionally interconnected, as demonstrated by the expression of many intracellular components assigned to both integrin-related and IGF-related cascades (Fig. 8).
Both methods are functionally interconnected at the referential levels, so that an activity in one system can cause an activity in the other system.
It is becoming increasingly clear that different classes of NC-RNAs are functionally interconnected, and that their coordinated interactions regulate cellular phenotypic changes in both physiological and pathological conditions [ 153].
The observations that both aglZ and romR mutations result in loss of A-motility suggest that the two units are functionally interconnected.
Actually, it is proposed that the bulk endocytic uptake phenotype and actin abnormalities are functionally interconnected [19].
10.7554/eLife.06547.038 Figure 7. ULK3 and CHMP4C are functionally interconnected within the abscission control pathway.
