The activity of RING ubiquitin ligases (E3s) depends on an interaction between the RING domain and ubiquitin conjugating enzymes (E2), but posttranslational events or additional structural elements, yet largely undefined, are frequently required to enhance or regulate activity.
In prostate cancer, ETS family members, such as ERG, ETV1, ETV4, and ETV5, are frequently overexpressed due to chromosomal translocations, but the molecular mechanisms by which they promote prostate tumorigenesis remain largely undefined.
Therefore, dendritic cells (DCs) pulsed with crude tumour cell homogenates or undefined peptide mixtures eluted from tumour cells were frequently used to augment glioma-reactive CTLs (Rutkowski et al, 2004; Yu et al, 2001, 2004; Yamanaka et al, 2003, 2005).
Meningitis in children is frequently associated with postural instability, which is often attributed to an undefined neurologic disorder but it could actually be due to vestibular impairment.
Yet the sources of their fanaticism are left undefined.
National practice patterns for such scenarios are currently undefined.
However, the functional consequences of most loci are largely undefined.
However, the biological functions of L3MBTL2 are largely undefined.
As for that global expansion, the details are still undefined.
Allfurther columns are currently undefined.
Its pathogenesis and subtypes are usually undefined.
