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Oligogenic inheritance where more than one variant are found to segregate in a pedigree is very likely in common diseases.
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When backcrossed into Col-0, ces-D was found to segregate in a 3 1 ratio.
134 One missense mutation (G399S) was found to segregate in a family with Parkinson's disease.
Moreover, no indel was found to segregate in our family dataset.
By phylogenetic analysis, the strain was found to segregate in the Mamastrovirus genogroup.
Subsequently, the same mutation was found to segregate with AD in a Swedish family [ 11].
Recently, a frameshift mutation in the potassium ion channel gene, KCNK18, was found to segregate with autosomal dominant MA in a multigenerational pedigree [44].
Five candidate genes were found to segregate with MA in one family.
127 Later, mutations in the GIGYF2 gene were found to segregate with typical Parkinson's disease in several small families.
Therefore, the six families were the only families in which these four EFHC1 mutations were found to segregate with JME.
In the MP7 population, 118 of the 384 SNPs were found to segregate using the BeadStudio software.
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