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Although the reason is not clear yet and requires further studies, a possibility is that in the absence of PARP-1 the DNA repair machinery is ineffective and therefore the cells are facilitated to undergo apoptotic cell death.
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It has been suggested that the integration is facilitated by the viral polymerase undergoing two subsequent template switches during minus-strand synthesis [ 37], although nonreplicative RNA recombination also may be a possibility [ 38].
"Each coordinator has to undergo training, which is facilitated by UNICEF, WHO and the government doctor," says Leema. "Coordinators train supervisors and volunteers.
Thus, the Ge nanocrystallites are undergoing an Ostwald ripening process [11] which also, in addition to the migration, appears to be facilitated by the Si interstitials.
The circular molecule undergoes interconversion into a dumbbell-shaped conformation that is facilitated by the IR.
Due to phosphorylation, the regulatory domain of TH undergoes a conformational change and dissociation of bound CA is facilitated.
In addition to the facile functionalization, many MOFs are known to undergo structural changes upon adsorption of different molecules ('breathing'), facilitating the design of, for instance, dynamic composites.
Mitochondria are known to undergo fragmentation on induction of apoptosis, which has been suggested to facilitate MOMP.
Within the structural framework of Cass2, a distinct loop feature extending from helix α2 edging the central sheet (residues 41 46) is proposed to undergo structural rearrangement so as to facilitate ligand entry.
Upon ligand binding, AhR is presumed to undergo a conformational change that exposes its N-terminal nuclear localization sequence, facilitating the nuclear translocation of the AhR ligand complex.
CHIP is known to undergo regulatory ubiquitination in cells and in vitro [ 8, 47, 48], which facilitates targeting of its substrates for proteasomal degradation [ 5].
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