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The consequences of this announcement are extremely significant.
But the public health gains are extremely significant".
We now know gut bacteria are extremely significant players within health.
Very few artists see royalties from their labels, even on big records (Universal claiming that the costs of Blurred Lines came to $6.9m indicate why that might be) but if you write a big song, the potential earnings from radio play, use in films, TV and advertising and so forth are extremely significant.
In contrast, rounding process and chamber location are extremely significant.
Pollution and environmental protection in the present century are extremely significant global problems.
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This admission is extremely significant.
"The pope's passing is extremely significant," Father Shaw said.
It's extremely significant in African-American history.
The latter discovery, made by J.R. Hicks (1932), is extremely significant.
The game is extremely significant, and NBC and CBS will profit by their broadcasts.
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