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The phrase "are extremely different" is correct and usable in written English.
You can use it to emphasize a significant difference between two or more subjects.
Example: "The two cultures are extremely different in their traditions and values."
Alternatives: "are vastly different" or "are markedly different".
Exact(49)
Waitlist – What's The Difference? Getting deferred at a university versus put on a waitlist are extremely different situations, but they do pose some similarities.
These are extremely different situations.
From country to country, dialects are extremely different.
But this time, Mr. Schoenholtz said, the circumstances are extremely different.
Despite their growing affinity, it became clear during that trip that they are "extremely different people," Dr. Steward said.
"She will have had the lead in the two plays that are most directly about that day, and they are extremely different takes on that time.
Similar(11)
It is extremely different.
It's extremely different.
So it's extremely different for me.
It's extremely different from now".
"I'm extremely different," he tells the camera, sullenly.
More suggestions(16)
are quite different
are extremely dissimilar
are extremely divergent
are terribly different
are highly different
are extremely various
are extremely disparate
are extremely different from each other
are extremely varied
is vitally different
be very different
being very different
is hugely different
are vastly different
are exceedingly different
are extraordinarily different
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com