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High-titer serologically detected male (SDM) antibody fragments are essential for specific binding to the SDM antigen and promoting its application.
A variety of proteins contain catalytic domains, which are essential for specific enzymatic functions.
However, spore walls are essential for specific types of stress resistance.
These proteins possess a Six domain in addition to an homeodomain, both of which are essential for specific interactions both with other proteins and with DNA.
Four cis-acting DNA-binding elements mapped on the CEA promoter region within 300 bp upstream of CEA translation starting point, especially, the first three elements are essential for specific CEA transcription (Hauck and Stanners, 1995; Richards et al, 1995a).
Integrated nuclease domains with excision activities are seen in the DICER proteins where two ribonuclease III domains cut double stranded RNAs, releasing 2 nt 3' end overhang 21 23 nt RNA molecules which are essential for specific cleavage of viral RNAs [ 20, 22].
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Muramatsu's laboratory (Hanada et al., 1996) first demonstrated that mammalian PAF53 was essential for specific rDNA transcription and that PAF53 levels were regulated in response to growth factors.
Thus, the combination of electrostatic and hydrophobic interactions is essential for specific binding.
Also DUBs harbour UBDs and the recognition and binding of a certain UBD to a specific ubiquitin linkage is thought to be essential for specific chain hydrolysis 45.
This is supported by the absence of the sentry glutamate in Sec7 which in the cytohesins is essential for specific plasma membrane targeting.
These observations suggest that the CD103→E-cadherin interaction is essential for specific T cell-mediated lysis of pancreatic cancer cell targets.
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