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Thus, determinants of receptor specificity reside within the flexible N-terminal segments of FGF19, although other regions within FGF19 are essential for maximum activation of FGFR4.
Thus for positioning sequences from genomes with multicopy repeats (i.e. most large eukaryote genomes) "soft masking" and associated extension options are essential for maximum specificity.
Earlier access of key populations to combination prevention interventions, combined with sustained political commitment and supportive environment for key populations, are essential for maximum impact of ART on the HIV epidemic in Vietnam.
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Consequently, a supply of both co-factors (folate and B12) and methyl donors were essential for maximum dairy performance.
Accurate connection over the whole contact area of the tubes and fins is essential for maximum heat exchange efficiency.
We have previously demonstrated that the localization of hFasL within rafts is essential for maximum induction of cell death.
Good adhesion of the fentanyl patch to the skin is essential for maximum efficacy, therefore patients must be instructed on the proper technique for patch application [ 30].
Future research should also include measures to determine the implementation strategies and compliance of prevention programmes as these factors appear to be essential for maximum effectiveness.
A disulfide linkage is usually thought to be essential for maximum cytotoxicity, but it is also necessary to chemically modify the antibody and the RIP to produce the disulfide bond [ 50].
Although artichoke can be regarded as a moderately salt resistant crop, the need to maintain low soil salinity levels is essential for maximum yields, since when salt concentration becomes too high, the size of the buds decreases [ 35].
Smokers in this age range have much to gain by reducing exposure to babies and children, and protecting their own health as quitting before age 40 is essential for maximum health benefits.
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