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Extracellular domains of Ptc1 are essential for accepting its ligand, Shh, and binding of Shh alleviates Smo repression, causing activation of Gli1-dependent transcription.
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Seven lysine residues in the Neh2 region have been shown to be essential for accepting Keap1-dependent ubiquitination by the Keap1-Cul3-Rbx1 E3 ubiquitin ligase complex, and is subsequently degraded by 26S proteasome [19].
It has been noted that "graphs are essential for effective communication in science;" [ 7] however, accepted data displays in health care research have been adopted largely on the basis of tradition rather than on the research of presentation methods [ 8].
It is widely accepted that Notch ligands expressed on TECs are essential for T cell lineage commitment and maturation [ 71– 71].
Bookings are essential for both.
They are essential for survival.
Dinner reservations are essential for weekends.
"Flagships are essential for this nation.
Dresses are essential for the girly look.
These things are essential for your future.
Some items are essential for certain characters.
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