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S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are essential compounds in the carbon metabolic cycle that have clinical implications in a broad range of disease conditions.
Polyamines (e.g. putrescine) derived from arginine catabolism are essential compounds for amastigote growth [ 15].
Nucleotides are structural units of nucleic acids, RNA and DNA, and are essential compounds in the energy transfer systems.
GS is responsible for the first step of ammonium assimilation and transformation into glutamine and glutamate, which are essential compounds in the amino acid biosynthetic pathway.
Nitrogen and sulfur assimilation pathways as well as the purine catabolism were lost in Pneumocystis spp. In the absence of assimilation from inorganic sources, nitrogen and sulfur are essential compounds which can be obtained from the degradation of purines, or from proteolysis.
20 21 In the present study, the ratio of acylcarnitine to carnitine in group A is significantly higher than that of cluster B, which may indicate that the activity of acyltransferases is higher in patients of group A than group B. Carnitine and its acyl esters acylcarnitines are essential compounds for the metabolism of fatty acids.
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Subjects of particular interest include alternative catalytic routes capable of replacing genes thought to be essential; compounds with unclear routes of catabolism which are capable of supporting growth and/or cellular respiration; regulatory and environmental perturbations of the stoichiometric network model; and investigations of what, exactly, constitutes gene essentiality.
Vitamins are essential small compounds to maintain normal activities.
SA and ortho-hydroxybenzoic acid are essential signaling phenolic compounds associated with plant development and tolerance to abiotic and biotic stresses (Raskin 1992; Khan et al. 2003, 2012).
Mesothelial cells are long, flat and slender, with a high cytoplasm/nucleoli ratio and specialized microvilli on their surface, which are essential in trapping compounds that have lubricant qualities to allow a frictionless environment.
As shown in Tables 1 and 2, evaluation studies in in vivo systems and further clinical testing of lead compounds are essential for establishing the effectiveness of the potential compounds.
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