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Artificial transcription factors based on zinc finger proteins are engineered to regulate a variety of genes relevant to regenerative medicine such as a zinc finger transcription factor is designed to regulate the gene for vascular endothelial growth factor (VEGF).
Synthetic riboswitches are engineered to regulate gene expression in response to a variety of non-endogenous small molecules, and a challenge to select this engineered response requires robust screening tools.
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Designer TALEs (dTALEs) are chimeric transcription factors that can be engineered to regulate gene expression in mammalian cells.
Water-soluble fullerenes can be engineered to regulate activation of mast cells (MC) and control MC-driven diseases in vivo.
In this work, surface functionalization was engineered to regulate the interactions between a PCM of polyethylene glycol (PEG) and internal/external surfaces of a support of SBA-15 and the crystallization/stabilization behavior of PEG, and yield desirable thermal properties of the PEG confined in SBA-15 channels.
Because numerous natural protein and RNA modules involved in c-di-GMP sensing have been discovered, various output modules can be engineered to regulate diverse biological activities by NIRW light.
Previously, RXR was engineered to be regulated by LG335, a synthetic inactive analog of the compound LGD1069 (also known as bexarotene, trade name Targretin®) [ 23, 24].
A bladder cell line was engineered to express a doxycycline (dox) regulated shRNA against PSCA.
Furthermore, DCs can be engineered to express co-stimulatory molecules and adhesion molecules or to down-regulate negative modulators, thereby increasing their T cell-activating ability.
Using this method, transcription factors may also be engineered to optimize cellular systems for improved pentose fermentation characteristics, because the metabolism of sugars is tightly regulated [ 96, 98].
It is engineered "to lock in hydration".
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