In order to take full advantage of the peculiar optical properties of quantum dot (QD) nanostructures, their band structure must be engineered to optimize a few relevant parameters.
Ta0-a, the gene encoding the mature antimicrobial peptide tachyplesin II, was engineered to optimize the coding sequence according to codon usage bias in yeast.
Next-generation TLR 7/8 agonists have been engineered to optimize the adjuvant activity while limiting systemic exposure and thus limiting systemic side effects.
Research designed to discover and conduct preclinical and clinical testing of these antibodies suggests a scientific vision for how intact monoclonal antibody (mAb) (singular and plural) or small antigen-binding fragments of mAb could be engineered to optimize the proteins for specific therapeutic applications.
In such a system, the receptor-channel assembly is engineered to optimize physical interactions between the two proteins so that the conformational changes induced by ligand binding to the receptor are transduced into changes in channel gating, resulting in modification of the recorded ionic current directly correlated with the ligand concentration.
Using this method, transcription factors may also be engineered to optimize cellular systems for improved pentose fermentation characteristics, because the metabolism of sugars is tightly regulated [ 96, 98].
The new sensors are based on a modular design, which includes a sensing element that exploits a sulfonamido-oxine (Sox) fluorophore for reporting phosphorylation, a recognition and specificity element based on reported docking domain motifs and a variable linker, which can be engineered to optimize the intermodule distance and relative orientation.
Mosaic immunogens are bioinformatically engineered to optimize coverage of global HIV-1 sequence diversity (7 – 12).
To meet the growing demands of large-scale applications, increase biogas productivity, and decrease energy consumption, biogas reactors have been chemically engineered to optimize heating and mixing and control reaction pathways.
Just keep in mind that natural coconut water contains less sugar (muscle fuel) and sodium (an important hydration electrolyte) than the average sports drink, which is engineered to improve and optimize athlete performance.
