Exact(3)
This study confirmed that CBZ and OXC are efficacious in a great majority of patients and that OXC is more tolerated in comparison with CBZ.
In addition, 6a c are efficacious in a rat arterial thrombosis, and are active in ADP- or PAF-induced in vitro platelet aggregation assay, suggesting that compounds 6a c also possess anti-thrombotic activities.
And in turn experimental methods can identify interventions that are efficacious in a controlled environment, which then need to be evaluated in an embedded system of care across a range of patients and settings, to determine who may benefit, in what ways, and under which circumstances.
Similar(57)
I could list literally a dozen more examples, but you get the idea: because we balkanize biomedical research, biomedical-research funding, and pharmaceutical industry drug development according to phenotypically classified diseases, the possibility that a drug that has failed the efficacy test in one disease might be efficacious in a completely different one has not permeated the culture.
Compound 22 was efficacious in a murine allergic inflammation model (ED50 ∼ 10 mg/kg).
Compound 8c was efficacious in a murine allergic inflammation model (ED50 30 mg/kg).
CBZ and OXC were confirmed to be efficacious in a large majority of patients, but the side effects caused withdrawal from treatment in an important percentage of patients.
CBZ and OXC were confirmed to be efficacious in a large majority of patients, but the side effects caused the withdrawal from treatment in an important percentage of patients.
Lead compound 10j was shown to be orally bioavailable in three species, distributed into adipose tissue in the mouse, and its (R) isomer 10j2 was efficacious in a primate pharmacodynamic model.
Compounds 12a c were efficacious in a rat arterial thrombosis model, and were active in ADP- or PAF-induced in vitro platelet aggregation assays, which suggests these compounds also possess anti-thrombotic activity.
Structure activity relationship studies led to the identification of 10c, which was efficacious in a diabetic ob/ob mouse model and reduced fasting and non-fasting blood glucose levels after ip dosing.
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