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Interestingly, Myc-driven human cancer cells strongly depend on glutamine and are dramatically sensitive to glutamine starvation (Yuneva et al., 2007).
These results strongly suggest that neither Orai1 nor TRPC1, which are dramatically sensitive to this drug, contribute subunits to the conducting pore of store-dependent channels in mRCC cells [ 3, 4].
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This subset of lung cancer is addicted to high ALK activity for malignant growth, and in general it is dramatically sensitive to ALK-targeted agents such as crizotinib.
CL-V5B cells are dramatically more sensitive (30-fold based on D10 values) to the cytotoxic effects of β-D-glucose-ifosfamide mustard as compared to parental V79B cells.
Compared to wild type, guard cells of ahk5-1 and ahk5-3 were dramatically less sensitive to H2O2 at various concentrations (Fig. 4 A, B).
Lula lysogens were dramatically more sensitive to UV irradiation compared to Lambda lysogens, displaying both a shorter resistance shoulder and a steeper viability decline (Fig. 4A) and generally behaving like a moderately-defective DNA repair mutant.
Despite this similarity, we report here that COX-2 oxygenation of 2-AG is dramatically more sensitive to inhibition by a series of acidic NSAIDs than is oxygenation of AA.
This technology has its pitfalls, such as low cellular radiolabelling efficiency, but it has the advantage of being dramatically more sensitive than MRI thereby giving insight into early migration/accumulation of injected cells in vivo.
In addition, levels of LCN-2, a sensitive and dynamic noninvasive biomarker for intestinal inflammation, are dramatically increased after TCDF exposure (Chassaing et al. 2012).
Moreover, robustness checks, presented in Additional file 1: Appendix D, showed that our results are not dramatically sensitive to the assumptions used for the algorithm.
YAHA is as fast and accurate as BWA-SW at finding the single best alignment per query and is dramatically faster and more sensitive than both SSAHA2 and MegaBLAST at finding all possible alignments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com